The total blood volume may be calculated by dividing the plasma volume measured with labeled albumin by the:

The correct approach to calculating total blood volume by using the plasma volume measured with labeled albumin involves applying the corrected plasmacrit. Corrected plasmacrit accounts for the proportion of blood volume that is made up of red blood cells and is a necessary adjustment when calculating total blood volume, as it reflects changes in the hematocrit that could affect the measurement.

When plasma volume is measured, it does not directly equate to total blood volume since blood consists of both plasma and cellular components. The corrected plasmacrit serves as a factor to estimate how much of the blood is cellular, which, when applied to the measured plasma volume, allows for an accurate calculation of total blood volume.

In contrast, the standard hematocrit alone does not take into account any specific variations or corrections needed for accurate blood volume estimations, while the blood volume factor and plasma concentration are not relevant in this context for calculating total blood volume from plasma volume. Therefore, utilizing the corrected plasmacrit aligns with standard practices in nuclear medicine and ensures a more precise measurement of total blood volume.