During a red cell sequestration study, counts are typically obtained from which of the following organs?

In a red cell sequestration study, counts are primarily obtained from the spleen. This organ plays a crucial role in filtering and removing aged or damaged red blood cells from circulation. The spleen is responsible for the sequestration and destruction of red cells, particularly during conditions where there is an abnormality in red blood cell turnover or in pathological states.

This study specifically assesses the function of the spleen in managing red blood cells and helps evaluate conditions such as splenomegaly or functional asplenia. Although other organs may have roles related to blood components, the spleen is the primary focus for this particular type of study due to its direct engagement in red cell sequestration and its ability to store red blood cells.

While the liver does have some involvement in the breakdown of blood components, and the kidneys have roles in red blood cell production and regulation through erythropoietin, they are not the main site of action for red cell sequestration. The heart is primarily involved in pumping blood and does not directly participate in the sequestration of red blood cells. Therefore, the selection of the spleen aligns with the objective of evaluating the red blood cell lifecycle and management.